Key result
The global eradication of poliomyelitis faces major challenges, including poor immunogenicity of the oral poliovirus vaccine in lower-income countries and the risk of vaccine-derived outbreaks.
Design
Review
Authors
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Continued surveillance for vaccine-derived polioviruses remains essential; leaves open optimization of oral vaccine performance in lower-income countries.
This review outlines the remaining challenges to global polio eradication, emphasizing the need to manage vaccine-derived polioviruses and improve surveillance.
Nicholas C. Grassly (2013) conducted a review in Poliomyelitis. Oral poliovirus vaccine (OPV) was evaluated. The global eradication of poliomyelitis faces major challenges, including poor immunogenicity of the oral poliovirus vaccine in lower-income countries and the risk of vaccine-derived outbreaks.
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