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August 12, 2020AJP Lung Cellular and Molecular PhysiologyOpen Access

Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients

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Key result

This review summarizes the pathophysiologic contributions of the renin-angiotensin system in hypertension and its possible correlation with poor outcomes in hypertensive patients with COVID-19.

Why the study?

Mortality from COVID-19 is high in hypertensive patients, but the role of components of the renin-angiotensin system beyond ANG II requires elucidation.

Design

Review

Authors

RSRodrigo P. Silva‐AguiarUniversidade Federal do Rio de JaneiroDPDiogo B. PeruchettiUniversidade Federal de Minas GeraisPRPatrícia R. M. RoccoUniversidade Federal do Rio de Janeiro

Discussion

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Implication

May guide RAS research in hypertensive COVID-19; leaves open practice implications without prospective data.

Structured PICO

P
Population
Hypertensive patients with COVID-19

This review highlights the potential role of the renin-angiotensin system, particularly angiotensin II and ACE2, in the pathogenesis and worsening of COVID-19 in hypertensive patients.

Cite This Study

Silva‐Aguiar et al. (2020) conducted a review in COVID-19 and hypertension. Renin-angiotensin system components was evaluated. This review summarizes the pathophysiologic contributions of the renin-angiotensin system in hypertension and its possible correlation with poor outcomes in hypertensive patients with COVID-19.

synapsesocial.com/papers/6a89727f41f4089922bd5df5https://doi.org/10.1152/ajplung.00286.2020

Topics

Hypertension managementCOVID-19 cardiovascular
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