March 31, 1981Biochemistry

Phosphorus-31 nuclear magnetic resonance studies of the adenosine 5'-triphosphate-calcium-G-actin complex

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Population

Adenosine 5'-triphosphate-calcium-G-actin complex

Comparison

Addition of urea (1.5 M and 6 M) vs Baseline state (no urea)

Design

Preclinical

Authors

MBManfred BrauerMedical Council of Canada BSBrian D. SykesHeart Failure / Cardiomyopathy

Discussion

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Implication

These G-actin ATP dynamics extend biophysical models; clinical cardiac relevance remains unexplored.

Structured PICO

Population

Adenosine 5'-triphosphate-calcium-G-actin complex

Intervention

Addition of urea (1.5 M and 6 M)

Comparator

Baseline state (no urea)

Outcome

Phosphorus-31 nuclear magnetic resonance spectra (exchange rate, rotational correlation time, and protein unfolding)surrogate

This basic science study characterizes the NMR properties and exchange dynamics of ATP bound to G-actin, demonstrating its structural stability and response to urea-induced unfolding.

Cite This Study

Brauer et al. (1981) studied this question.

synapsesocial.com/papers/6a897b76ab4588dbccfb932e https://doi.org/10.1021/bi00510a050

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Phosphorus-31 nuclear magnetic resonance studies of the adenosine 5'-triphosphate-calcium-G-actin complex

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Phosphorus-31 nuclear magnetic resonance studies of the adenosine 5'-triphosphate-calcium-G-actin complex

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider