Key result
L-arginine infusion at doses of 50 and 150 mg/kg significantly increased muscle capillary blood flow in rats without causing hypotension.
Why the study?
Does intravenous L-arginine infusion increase peripheral capillary blood flow without affecting blood pressure in normotensive rats?
Population
99 male Sprague-Dawley rats weighing 310-490 g (66 for laser Doppler study, 33 for microsphere study)
Comparison
Intravenous L-arginine infusion at doses of 15… vs Intravenous saline or nicardipine for 30 minutes
Design
Preclinical
Follow-up
30 minutes
Authors
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May support preclinical exploration of L-arginine for microperfusion; leaves open human translation and clinical relevance.
Does intravenous L-arginine infusion increase peripheral capillary blood flow without affecting blood pressure in normotensive rats?
Low-dose L-arginine increases skeletal muscle microperfusion without causing hypotension in resting rats, suggesting potential utility for improving muscle blood flow.
Ohta et al. (2007) studied Normotensive rats. L-arginine vs. Control group was evaluated on Capillary blood flow and mean blood pressure. L-arginine infusion at doses of 50 and 150 mg/kg significantly increased muscle capillary blood flow in rats without causing hypotension.
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