Key result
The rs4918 polymorphism of the AHSG gene was not significantly associated with coronary artery calcification scores in patients with coronary artery disease (p=0.792).
Why the study?
Fetuin-A is a calcification inhibitor that prevents coronary artery calcification, but the correlation between the AHSG rs4918 polymorphism and coronary artery calcification in CAD patients required evaluation.
Does the rs4918 polymorphism of the AHSG gene correlate with coronary artery calcification in patients with coronary artery disease?
Case-Control (n=123)
Does the rs4918 polymorphism of the AHSG gene correlate with coronary artery calcification in patients with coronary artery disease?
p-value: p=0.792
The rs4918 polymorphism of the AHSG gene is not significantly associated with overall coronary artery calcification scores in patients with CAD.
Does not support rs4918 testing for CAC stratification in CAD; leaves open AHSG roles in vascular calcification.
Objectives: Fetuin-A is a circulating calcification inhibitor that prevents coronary artery calcification (CAC) by increasing calcium phosphate solubility and inhibiting VSMC differentiation and apoptosis. In this study, we investigated the correlation between rs4918 and CAC in patients with coronary artery disease (CAD). Methods: Forty-two healthy individuals and eighty-one CAD patients were recruited in the present study. The CAC score (CACS) was measured by CT angiography and the genotype analysis of rs4918 single-nucleotide polymorphism SNP was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results: The CACS was significantly higher in CAD patients compared to healthy individuals (p < 0.001); however, there was no significant difference between the mean CACS in the presence and absence of rs4918 (p = 0.792). The mean calcium score of the left main coronary artery (LMCA) was significantly lower in carriers of the rs4918 allele (p = 0.036). The frequency of rs4918 SNP was almost similar in the control group and CAD patients (p = 0.846). Conclusions: in patients with CAD, we found no significant association between rs4918 SNP and CACS, indicating that carriers of this allele are not at increased risk of developing cardiovascular diseases compared with those without.
No takes yet. Share an insight, caveat, or question.
Ahmadihosseini et al. (2020) conducted a case-control in Coronary artery disease (n=123). rs4918 polymorphism of AHSG gene vs. Absence of rs4918 allele was evaluated on Coronary artery calcification score (CACS) (p=0.792). The rs4918 polymorphism of the AHSG gene was not significantly associated with coronary artery calcification scores in patients with coronary artery disease (p=0.792).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: