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August 22, 2026Heart and VesselsOpen Access

Authors’ reply: Risk stratification and determinants of cardiac recovery in hemodialysis patients with reduced ejection fraction

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Key result

Greater post-dialysis weight reduction is associated with attenuated left ventricular ejection fraction recovery, which may reflect underlying disease severity rather than harmful dialysis practices.

Why the study?

Does weight reduction affect LVEF recovery in hemodialysis patients with reduced ejection fraction?

Population

Hemodialysis patients with reduced ejection fraction

Design

Editorial

Authors

TKToshikazu KashiyamaSumitomo Hospital

Discussion

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Implication

Greater weight reduction during hemodialysis is associated with attenuated LVEF recovery, though this may reflect underlying disease severity rather than a causal detrimental effect of ultrafiltration.

Structured PICO

Does weight reduction affect LVEF recovery in hemodialysis patients with reduced ejection fraction?

P
Population
Hemodialysis patients with reduced ejection fraction
E
Exposure
Weight reduction / ultrafiltration
O
Outcome
LVEF recoverysurrogate

Greater weight reduction during hemodialysis is associated with attenuated LVEF recovery, though this may reflect underlying disease severity rather than a causal detrimental effect of ultrafiltration.

Limitations

  • Observational nature of the study precludes firm conclusions.
  • Limited use of guideline-directed therapies.
  • Longitudinal post-dialysis weight reduction cannot be interpreted as a direct measure of ultrafiltration intensity.

Cite This Study

Toshikazu Kashiyama (2026) conducted a letter in Hemodialysis with reduced ejection fraction. Post-dialysis weight reduction was evaluated on Left ventricular ejection fraction (LVEF) recovery. Greater post-dialysis weight reduction is associated with attenuated left ventricular ejection fraction recovery, which may reflect underlying disease severity rather than harmful dialysis practices.

synapsesocial.com/papers/6a898323ca7ade938187f3e8https://doi.org/10.1007/s00380-026-02752-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renal Dysfunction in Patients With Heart Failure With Preserved Versus Reduced Ejection Fraction2012 · 203 citations
  2. 2Risk stratification and determinants of cardiac recovery in hemodialysis patients with reduced ejection fraction2026 · 1 citations
  3. 3Renal Insufficiency and Heart Failure2004 · 705 citations
  4. 4Predictive Performance of Renal Function Equations for Patients with Chronic Kidney Disease and Normal Serum Creatinine Levels2002 · 411 citations
  5. 5Anemia and Renal Insufficiency Are Independent Risk Factors for Death among Patients with Congestive Heart Failure Admitted to Community Hospitals2002 · 466 citations