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The effects of cortisol administration on the α2-AP globulin response to tissue injury were studied in adrenalecto-mized, sham-operated, and intact rats. Ad-renalectomy significantly reduced the response to challenge. The response could be partially or completely restored, or suppressed depending upon the dosage of the hormone. It was concluded that the adrenal cortex has a permissive role in the synthesis of α2-AP globulin of rat serum.
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Weimer et al. (1966) studied this question.
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