Population
Rats raised in room air and in two environments that induce pulmonary arterial hypertension
Comparison
Hypoxia or hyperoxia environments to induce… vs Room air (control)
Design
Preclinical
Authors
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Hypothesis-generating for fractal dimension as a PAH vascular biomarker in animals; leaves open human validation before any clinical use.
Fractal dimension analysis of pulmonary arteries can quantify pathologic structural changes in pulmonary arterial hypertension, demonstrating reduced vascular complexity in hypertensive models.
Boxt et al. (1994) studied this question.
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