Key result
The presence of type 2 diabetes in patients with coronary heart disease was associated with significantly higher severity of coronary atherosclerosis (median Gensini score 11 vs 0, p=0.005).
Why the study?
Does the presence of type 2 diabetes aggravate the severity of coronary atherosclerosis and markers of inflammation and stress in patients with coronary artery disease?
Observational (n=336)
No
Does the presence of type 2 diabetes aggravate the severity of coronary atherosclerosis and markers of inflammation and stress in patients with coronary artery disease?
Answers are grounded in this paper and cite their sources.
Type 2 diabetes exacerbates coronary artery disease severity and is associated with increased inflammation, endothelial dysfunction, and oxidative stress.
Results of this study present the features of the severity of coronary atherosclerosis, evaluated by the Gensini score, depending on the presence of T2D (type 2 diabetes). The presence of T2D aggravates the course of coronary heart disease due to the more pronounced processes of inflammation, endothelial dysfunction, and oxidative and cellular stress.
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Kotova et al. (2020) conducted an observational in Coronary Heart Disease and Type 2 Diabetes (n=336). Type 2 diabetes vs. Patients without type 2 diabetes was evaluated on Gensini score (severity of coronary atherosclerosis) (p=0.005). The presence of type 2 diabetes in patients with coronary heart disease was associated with significantly higher severity of coronary atherosclerosis (median Gensini score 11 vs 0, p=0.005).
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