Key result
Obese patients with type 2 diabetes exhibited significantly elevated biomarkers of systemic inflammation and endothelial dysfunction, which were strongly correlated with one another.
Case-Control (n=80)
No
Absolute Event Rate: 16.34% vs 10.16%
p-value: p=<0.05
Obese patients with type 2 diabetes exhibit significantly elevated and strongly correlated levels of systemic inflammatory and endothelial dysfunction biomarkers, highlighting a potential mechanism for their increased cardiovascular risk.
Supports inflammation-endothelial link to CV risk in obese T2D; hypothesis-generating, should not yet change practice.
Background: Systemic inflammation and endothelial dysfunction induce vascular complications of diabetes mellitus that impose a huge burden on diabetes mellitus complications management.
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Mohammed H Saiem Al Dahr (2017) conducted a case-control in Type 2 Diabetes and Obesity (n=80). Obesity and Type 2 Diabetes vs. Healthy non-diabetic subjects was evaluated on Serum C-reactive protein (CRP) levels (mg/dl) (p=<0.05). Obese patients with type 2 diabetes exhibited significantly elevated biomarkers of systemic inflammation and endothelial dysfunction, which were strongly correlated with one another.
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