Key result
Applying a global pulse-disturbance to three models of cardiac muscle eliminated spiral waves and decreased the frequency of the cardiac muscle, restoring normal oscillation.
Why the study?
Common methods to remove life-threatening spiral waves in cardiac muscle apply local disturbances that accelerate beating and aggravate ventricular tachycardia.
Does a global pulse-disturbance eliminate spiral waves in models of cardiac muscle?
Does a global pulse-disturbance eliminate spiral waves in models of cardiac muscle?
A global pulse-disturbance can eliminate spiral waves in cardiac muscle models, offering a theoretical approach to preventing ventricular tachycardia and fibrillation.
May inform arrhythmia termination strategies; leaves open translation from models to clinical use.
Removal of spiral waves in cardiac muscle is necessary because of their threat to life. Common methods for this removal are to apply a local disturbance to the media, such as a periodic forcing. However, most of these methods accelerate the beating of the cardiac muscle, resulting in the aggravation of the ventricular tachycardia, which directly threatens life. In the present study, in order to clear off spiral waves, a global pulse-disturbance is applied to the media based on three models of cardiac muscle. It is found that the spiral waves are eliminated and the frequency of the cardiac muscle is decreased in a short time, and finally, the state of the medium reaches the normal oscillation, which supports a target waves. Our method sheds light on the removal of spiral waves in cardiac muscle and can prevent the ventricular tachycardia as well as the ventricular fibrillation.x
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Gao et al. (2021) studied Spiral waves in cardiac muscle (ventricular tachycardia/fibrillation). Global pulse-disturbance was evaluated on Elimination of spiral waves and decrease in frequency of cardiac muscle. Applying a global pulse-disturbance to three models of cardiac muscle eliminated spiral waves and decreased the frequency of the cardiac muscle, restoring normal oscillation.
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