Key result
Guideline-directed medical therapy remains underutilized in patients with heart failure with reduced ejection fraction and secondary mitral regurgitation.
Highlights the significant underutilization of guideline-directed medical therapy in patients with HFrEF and secondary mitral regurgitation undergoing transcatheter edge-to-edge repair.
Underutilization of GDMT in patients with HFrEF and SMR. Proportion of patients who were prescribed triple, double, single, and no GDMT for management of heart failure (upper) and prescription rate for each GDMT class (lower) in selected HF and M-TEER studies. *Data for the COAPT trial were obtained from Cox et al.11 CHAMP-HF, Change the Management of Patients with Heart Failure; COAPT, Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation; EuroSMR, European Registry of Transcatheter Repair for Secondary Mitral Regurgitation; HFrEF, heart failure with reduced ejection fraction; GDMT, guideline-directed medical therapy; MITRA-FR, Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients with Severe Secondary Mitral Regurgitation; M-TEER, transcatheter edge-to-edge mitral valve repair; STS/ACC TVT, Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy.
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Tomii et al. (2023) conducted a review in Heart failure with reduced ejection fraction and secondary mitral regurgitation. Guideline-directed medical therapy was evaluated on GDMT prescription rates. Guideline-directed medical therapy remains underutilized in patients with heart failure with reduced ejection fraction and secondary mitral regurgitation.
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