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February 8, 1980JAMA

Tamoxifen and Thromboembolism

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Why the study?

Does tamoxifen increase the risk of thromboembolism in patients with a known predisposition to thrombosis?

Population

A 72-year-old woman with metastatic pleural effusion and bone disease from breast cancer, with a history of…

Design

Case_report

Follow-up

1 month

Authors

AHAlex Hendrick

Discussion

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Overview

May warrant caution with tamoxifen in thrombosis-prone patients; hypothesis-generating and requires confirmation in controlled studies.

Structured PICO

Does tamoxifen increase the risk of thromboembolism in patients with a known predisposition to thrombosis?

P
Population
A 72-year-old woman with metastatic pleural effusion and bone disease from breast cancer, with a history of arterial occlusion (right brachial and ulnar arteries) during chemotherapy (n=1).
I
Intervention
Tamoxifen citrate 10 mg twice daily
O
Outcome
Thromboembolic events / safetysafety

This case report raises concerns about the safety of tamoxifen in patients with a known predisposition to thrombosis due to its potential paradoxical estrogenic effects.

Cite This Study

Alex Hendrick (1980) studied this question.

synapsesocial.com/papers/6a899b90ea82e62cf6fd4a73https://doi.org/10.1001/jama.1980.03300320012005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thrombosis of tibial arteries in a patient receiving tamoxifen therapy1995 · 14 citations
  2. 2Tamoxifen treatment and risk of deep venous thrombosis and pulmonary embolism2009 · 187 citations
  3. 3The influence of tamoxifen in vivo on the main natural anticoagulants and fibrinolysis1993 · 47 citations
  4. 4Abstract PS3-09-12: Thrombophilia Screening Prior to Tamoxifen Therapy in Early-Stage Hormone Receptor-Positive Breast Cancer: A Three-Year Retrospective Study2026
  5. 5Prophylaxis for venous thromboembolism during treatment for cancer: questionnaire survey2003 · 43 citations