Key result
The deletion (D) allele for the ACE gene was significantly more frequent in patients with premature coronary artery disease compared to healthy controls (96% vs 61%).
Why the study?
The relationship between the early risk of CAD and renin-angiotensin genes and endothelial nitric oxide synthase in the Iranian population was unknown.
Do ACE I/D and eNOS-786 gene polymorphisms increase the risk of premature coronary artery disease in an Iranian population?
Case-Control (n=135)
Yes
Do ACE I/D and eNOS-786 gene polymorphisms increase the risk of premature coronary artery disease in an Iranian population?
The ACE DD genotype is significantly associated with premature coronary artery disease in the Iranian population, whereas the eNOS-786 polymorphism showed no such association.
ACE I/D polymorphism associated with premature CAD risk; leaves open whether genotyping adds value to clinical risk models in Iranians.
INTRODUCTION: The study of polymorphisms and their relationship with diseases is very important for risk assessment. The aim of this study was to determine the relationship between early risk of coronary artery disease(CAD) with renin-angiotensin(RAS) genes and endothelial nitric oxide synthase(eNOS) in a sample of the Iranian population. METHODS & MATERIALS: In this cross-sectional study, 63 patients with premature CAD and 72 healthy samples were enrolled. Polymorphism of the promotor region of eNOS- and ACE-I/D (Angiotensin Converting Enzyme-I/D) polymorphism was evaluated. Polymerase chain reaction (PCR) test and PCR-RFLP (Restriction Fragment Length Polymorphism) was performed for ACE and eNOS-786 gene, respectively. RESULTS: The frequency of deletion(D) for the ACE gene was significantly higher in patients(96% versus 61%; P < 0.001). Conversely, the number of defective C alleles for the eNOS gene was similar in both groups (p > 0.9). CONCLUSION: ACE polymorphism seems to be an independent risk factor for premature CAD.
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Poorzand et al. (2023) conducted a case-control in Premature coronary artery disease (n=135). ACE I/D and eNOS gene polymorphisms vs. Healthy controls was evaluated on Frequency of deletion (D) allele for the ACE gene (p=<0.001). The deletion (D) allele for the ACE gene was significantly more frequent in patients with premature coronary artery disease compared to healthy controls (96% vs 61%).
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