Key result
The deletion (D) allele of the ACE gene was significantly more frequent in patients with premature coronary artery disease compared to healthy controls (95.2% vs 61.1%, p<0.001).
Why the study?
Evaluating polymorphisms and their relationship with diseases is important for risk assessment, motivating this study to assess the link between early risk of CAD and RAS and eNOS genes in an Iranian sample.
Case-Control (n=135)
Yes
The ACE DD genotype is significantly associated with premature coronary artery disease in an Iranian population, whereas the eNOS-786 polymorphism is not.
May link RAS/eNOS polymorphisms to premature CAD risk in Iranians; hypothesis-generating and requires prospective validation before clinical use.
Introduction: The study on polymorphisms and their relationship with diseases is very important for risk assessment. The aim of this study was to determine the relationship between early risk of coronary artery disease(CAD) with renin angiotensin(RAS) genes and endothelial nitric oxide synthase(eNOS) gene in a sample of the Iranian population. Methods & Materials: In this cross-sectional study, 63 patients with premature CAD and 72 healthy samples were enrolled. Polymorphism of the promotor region of eNOS- and ACE-I/D(Angiotensin Converting Enzyme-I/D) polymorphism were evaluated. Polymerase chain reaction(PCR) test and PCR-RFLP(Restriction Fragment Length Polymorphism) was performed for ACE and eNOS-786 gene, respectively. Results: The frequency of deletion(D) for ACE gene was 96% for patients and 61% for healthy controls and was significantly higher in patients(P<0.001). Conversely, the number of defective C allele for eNOS gene was similar in both groups(p>0.9). Conclusion: ACE polymorphism seems to be an independent risk factor for premature CAD.
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Poorzand et al. (2022) conducted a case-control in Premature coronary artery disease (n=135). ACE I/D and eNOS-786 gene polymorphisms vs. Healthy controls was evaluated on Frequency of deletion (D) allele for ACE gene (p=<0.001). The deletion (D) allele of the ACE gene was significantly more frequent in patients with premature coronary artery disease compared to healthy controls (95.2% vs 61.1%, p<0.001).
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