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Does not support changes in hypertension care; leaves open validation of remodeling targets in prospective trials.
hronic hypertension leads to adaptive processes in the heart, called remodeling, which are characterized by hypertrophic changes of cardiomyocytes and by structural alterations of the extracellular matrix. Although these processes are initially compensatory and preserve cardiac contractile performance, they finally lead to left ventricular (LV) dilatation and heart failure. Thus, factors playing a crucial role in remodeling are promising therapeutic targets.
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Panek et al. (2006) studied this question.
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