Key result
The TC or CC genotypes of the T29C TGFβ1 gene polymorphism were more prevalent in hypertensives with LVH and associated with microalbuminuria and worse left ventricular function (P < .05).
Why the study?
Is the T29C TGFβ1 gene polymorphism associated with altered left ventricular geometry, function, and biomarker levels in hypertensive subjects?
Observational (n=433)
Is the T29C TGFβ1 gene polymorphism associated with altered left ventricular geometry, function, and biomarker levels in hypertensive subjects?
p-value: p=< .05
The T29C TGFβ1 gene polymorphism (TC or CC genotypes) identifies a subset of hypertensive patients with more severe left ventricular hypertrophy, worse cardiac function, and greater target organ damage.
May flag higher-risk hypertensives; leaves open whether genotyping refines risk stratification or therapy.
The distribution of the T29C TGFβ1 gene polymorphism was analyzed in 198 hypertensives with left ventricular hypertrophy (LVH) and in 235 hypertensives without LVH. Circulating TGFβ1 levels, procollagen type III levels, microalbuminuria, and left ventricular geometry and function were evaluated in all the hypertensives with LVH subgrouped according to T29C TGFβ1 gene polymorphism. Circulating TGFβ1 was evaluated by ELISA technique, procollagen type III by a specific radioimmunoassay, microalbuminuria by radioimmunoassay, and left ventricular geometry and function by echocardiography. All groups were comparable for gender, age, and sex. Regarding T29C TGFβ1 gene polymorphism, prevalence of TC or CC genotypes was significantly (P < .05) higher in hypertensives with LVH than hypertensives without LVH TC and CC LVH hypertensives were characterized by a higher prevalence of subjects with microalbuminuria (P < .05 TC and CC versus TT), by increased levels of TGFβ1, procollagen type III, urinary albumin excretion, LVM, LVM/h(2.7), and lower values of left ventricular ejection fraction (P < .05 TC and CC versus TT). Our data suggest that T29C TGFβ1 gene polymorphism was associated with clinical characteristics adequate to recognize a subset of LVH hypertensives with a higher severity of hypertension.
No takes yet. Share an insight, caveat, or question.
Scaglione et al. (2010) conducted an observational in Hypertension with and without left ventricular hypertrophy (n=433). T29C TGFβ1 gene polymorphism (TC or CC genotypes) vs. TT genotype and hypertensives without LVH was evaluated on Prevalence of TC or CC genotypes and association with microalbuminuria, left ventricular mass, and ejection fraction (p=< .05). The TC or CC genotypes of the T29C TGFβ1 gene polymorphism were more prevalent in hypertensives with LVH and associated with microalbuminuria and worse left ventricular function (P < .05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: