Key result
Mechanical heart valves showed no statistically significant difference in combined endpoints of mortality, reoperation, haemorrhage, and stroke compared to biological valves (p=0.28).
Why the study?
Do mechanical prostheses improve outcomes compared to biological prostheses in children and adolescents with rheumatic heart disease undergoing valve replacement?
Population
73 patients with rheumatic heart disease under the age of 18 years, who underwent replacement of heart…
Comparison
Mechanical heart valve prostheses (n=52) vs Biological heart valve prostheses (n=19)
Design
Cohort
Follow-up
up to 8 years
Authors
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No difference in combined outcomes observed; leaves open optimal valve choice in pediatric RHD pending randomized data.
Cohort (n=73)
No
Do mechanical prostheses improve outcomes compared to biological prostheses in children and adolescents with rheumatic heart disease undergoing valve replacement?
p-value: p=0.28
Biological prostheses offer a viable alternative to mechanical valves in pediatric patients with rheumatic heart disease who have difficulties or risks with anticoagulation, as combined outcomes did not significantly differ.
Travancas et al. (2009) conducted a cohort in Rheumatic heart disease (n=73). Mechanical heart valves vs. Biological heart valves was evaluated on Combined endpoints of mortality, reoperation, haemorrhage, and stroke (p=0.28). Mechanical heart valves showed no statistically significant difference in combined endpoints of mortality, reoperation, haemorrhage, and stroke compared to biological valves (p=0.28).
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