Key result
Mechanical prostheses linked to ~80% fewer re-operations vs. bioprostheses in children under 12.
Why the study?
Valve replacement outcomes in children under 12 years old, including differences between biological and mechanical prostheses, required evaluation.
Do mechanical prostheses reduce re-operations and mortality compared to biological prostheses in children under 12 years old undergoing valve replacement?
Comparison
Mechanical prostheses vs biological prostheses
Design
Cohort study
Follow-up
Mean 5.8 years
Authors
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May support mechanical prostheses to reduce reoperations in young children; leaves open randomized confirmation and mortality effects.
Cohort (n=44)
No
Do mechanical prostheses reduce re-operations and mortality compared to biological prostheses in children under 12 years old undergoing valve replacement?
Absolute Event Rate: 12.5% vs 63.3%
p-value: p=0.002
In children under 12 years old, mechanical prostheses are associated with significantly fewer re-operations and lower rates of infectious endocarditis compared to biological prostheses.
Atik et al. (1999) conducted a cohort in Valve disease requiring replacement (n=44). Mechanical prostheses vs. Biological prostheses was evaluated on Re-operation (p=0.002). Mechanical prostheses were associated with significantly fewer re-operations (12.5% vs 63.3%, p=0.002) and less infectious endocarditis compared to biological prostheses in children under 12.
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