What question did this study set out to answer?

To determine whether quinidine and pronethalol retain their protective effects against acetylstrophanthidin-induced ventricular arrhythmias following reserpine-induced catecholamine depletion.

September 1, 1966Circulation ResearchOpen Access

Effect of Quinidine and Pronethalol on Acetylstrophanthidin-Induced Ventricular Arrhythmia in Cats Treated with Reserpine

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Why the study?

Do quinidine and pronethalol prevent acetylstrophanthidin-induced ventricular arrhythmia in cats depleted of catecholamines by reserpine?

Population

Cats (preclinical model)

Comparison

Quinidine and pronethalol vs Normal animals (without reserpine pretreatment)

Design

Preclinical

Authors

BLBarrie LevittUniversity of North Carolina at Chapel Hill JRJay RobertsUniversity of the Sciences

Discussion

Member takes

Implication

Quinidine and pronethalol's antidigitalis effects appear catecholamine-dependent; leaves open translation to clinical arrhythmia management.

Key Points

To determine whether quinidine and pronethalol retain their protective effects against acetylstrophanthidin-induced ventricular arrhythmias following reserpine-induced catecholamine depletion.
Tested the arrhythmia-inducing dose of acetylstrophanthidin during vagal stimulation in cats receiving quinidine, pronethalol, or reserpine.
Evaluated changes in sinoatrial nodal rate and susceptibility to ventricular arrhythmias in normal versus reserpine-pretreated feline models.
Quinidine, pronethalol, and reserpine each raised the threshold dose of acetylstrophanthidin required to induce arrhythmias during vagal stimulation in control animals.
Pretreatment with reserpine abolished the antiarrhythmic efficacy of both quinidine and pronethalol against acetylstrophanthidin-induced ventricular arrhythmias.
Pronethalol significantly reduced the sinoatrial nodal rate in untreated cats but exerted no detectable effect on heart rate following catecholamine depletion with reserpine.

Structured PICO

Do quinidine and pronethalol prevent acetylstrophanthidin-induced ventricular arrhythmia in cats depleted of catecholamines by reserpine?

Population

Cats (preclinical model)

Intervention

Quinidine and pronethalol

Comparator

Normal animals (without reserpine pretreatment)

Outcome

Acetylstrophanthidin-induced ventricular arrhythmiasurrogate

The antidigitalis effect of quinidine and pronethalol appears to be mediated by their ability to diminish adrenergic nervous activity, as they lose efficacy after catecholamine depletion with reserpine.

Cite This Study

Levitt et al. (1966) studied this question.

synapsesocial.com/papers/6a89af46abe412682d92fa43 https://doi.org/10.1161/01.res.19.3.622

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Implication

Quinidine and pronethalol's antidigitalis effects appear catecholamine-dependent; leaves open translation to clinical arrhythmia management.

Effect of Quinidine and Pronethalol on Acetylstrophanthidin-Induced Ventricular Arrhythmia in Cats Treated with Reserpine

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of Quinidine and Pronethalol on Acetylstrophanthidin-Induced Ventricular Arrhythmia in Cats Treated with Reserpine

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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