Why the study?
Does intravenous procaine amide hydrochloride induce ectopic ventricular activity in patients with cardiac arrhythmias?
Population
55 patients with various auricular and ventricular arrhythmias
Design
Case_series
Follow-up
During and after intravenous administration
Authors
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Hypothesis-generating for procainamide safety in arrhythmias; leaves open rare ventricular acceleration for controlled trials.
Does intravenous procaine amide hydrochloride induce ectopic ventricular activity in patients with cardiac arrhythmias?
Intravenous procaine amide hydrochloride appears generally safe regarding drug-induced ectopic ventricular activity, though rare cases of ventricular acceleration may occur.
John L. Denney (1952) studied this question.
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