Why the study?
Do nucleosides improve left ventricular function in an isolated dog heart model of acute left ventricular failure?
Population
15 isolated dog hearts with acute left ventricular failure produced by exposure to elevated aortic pressure
Comparison
Nucleosides vs Control and failure periods (baseline)
Design
Preclinical
Authors
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Does not support clinical use in acute LV failure; leaves open nucleoside inotrope investigation in translational models.
Do nucleosides improve left ventricular function in an isolated dog heart model of acute left ventricular failure?
In an isolated dog heart model, specific nucleosides (guanosine, inosine, thymidine, and uridine) act as positive inotropes capable of restoring ventricular function during acute left ventricular failure.
Buckley et al. (1959) studied this question.
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