January 1, 1987AJP Heart and Circulatory Physiology

Cell-to-cell diffusion of fluorescent dyes in paired ventricular cells

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Population

Enzymatically isolated paired ventricular cells of the guinea pig heart

Design

Preclinical

Authors

III. ImanagaFukuoka University MKMasaki KameyamaShinshu University HIHiroshi IrisawaDokkyo Medical University

Discussion

Member takes

Implication

Does not alter clinical practice; leaves open whether guinea pig gap junction permeability applies to human myocardium.

Structured PICO

Population

Enzymatically isolated paired ventricular cells of the guinea pig heart

Intervention

Fluorescent dyes of various molecular sizes (Fluorescein sodium, 6-carboxyfluorescein, Lucifer yellow CH, lissamine rhodamine B-200, tetraglycine-conjugated lissamine rhodamine B-200) introduced via patch-clamp pipette

Outcome

Intracellular and cell-to-cell diffusion (diffusion coefficient and gap-junctional membrane permeability)surrogate

The critical pore size of the ventricular gap junction in guinea pig hearts is large enough to permit passage of molecules up to at least 859 molecular weight.

Cite This Study

Imanaga et al. (1987) studied this question.

synapsesocial.com/papers/6a89b3dc1acf8e321fbd652a https://doi.org/10.1152/ajpheart.1987.252.1.h223

View Full Paper

Ask AI

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Cell-to-cell diffusion of fluorescent dyes in paired ventricular cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cell-to-cell diffusion of fluorescent dyes in paired ventricular cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider