Key result
Maternal diabetes was strongly associated with congenital heart disease (OR 6.3; 95% CI 2.7-14.6), followed by syndromes (OR 5.1) and maternal smoking (OR 4.0).
Why the study?
To investigate the association of maternal diabetes, maternal smoking, and syndromes with congenital heart disease in patients attending a cardiology clinic.
Are maternal diabetes, maternal smoking, and syndromes associated with an increased risk of congenital heart disease?
Case-Control (n=388)
No
Are maternal diabetes, maternal smoking, and syndromes associated with an increased risk of congenital heart disease?
Odds Ratio: 6.3 (95% CI 2.7–14.6)
Maternal diabetes, maternal smoking, and genetic syndromes are strongly associated with an increased risk of congenital heart disease.
Objective: To investigate the association of maternal diabetes, maternal smoking and syndromes with congenital heart disease (CHD) in patients attending Aljalila cardiology clinic between January 2020 and May of 2020. Methods: A case control study to assess the association of maternal diabetes, maternal smoking and syndromes with CHD. All patients that presented to the clinic between January 2020 and May of 2020 were included. An interviewer administered questionnaire was used to record the presence of maternal diabetes, maternal smoking, and the type of syndrome and type of CHD. Patients with CHD were included in the case group and patients who did not have CHD were in the control group. Age, gender, and nationality were also collected from the hospital records. Fisher exact test and logistic regression was used to analyze the results. Results: A total of 177 cases and 211 controls were recruited. All the risk factors increase the risk of CHD, with maternal diabetes (OR 6.3, 95% CI 2.7-14.6) having the strongest association, then syndromes (OR 5.1, 95% CI 2.3-11.3) and lastly maternal smoking (OR 4.0, 95% CI 1.0-16.3). The most common type of CHD is ventricular septal defect.
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Samah Alasrawi (2021) conducted a case-control in Congenital heart disease (CHD) (n=388). Maternal diabetes vs. Absence of maternal diabetes was evaluated on Congenital heart disease (OR 6.3, 95% CI 2.7-14.6). Maternal diabetes was strongly associated with congenital heart disease (OR 6.3; 95% CI 2.7-14.6), followed by syndromes (OR 5.1) and maternal smoking (OR 4.0).
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