Key result
Maternal diabetes (OR 6.3; 95% CI 2.7-14.6), syndromes (OR 5.1; 95% CI 2.3-11.3), and maternal smoking (OR 4.0; 95% CI 1.0-16.3) were significantly associated with congenital heart disease.
Why the study?
The study was conducted to investigate the association of maternal diabetes, maternal smoking, and syndromes with congenital heart disease in patients attending a cardiology clinic.
Are maternal diabetes, maternal smoking, and syndromes associated with an increased risk of congenital heart disease in children?
Case-Control (n=388)
No
Are maternal diabetes, maternal smoking, and syndromes associated with an increased risk of congenital heart disease in children?
Maternal diabetes, maternal smoking, and genetic syndromes are strongly associated with congenital heart disease in a UAE pediatric cardiology cohort.
Objective: To investigate the association of maternal diabetes, maternal smoking and syndromes with congenital heart disease (CHD) in patients attending Aljalila cardiology clinic between January 2020 and May of 2020. Methods: A case control study to assess the association of maternal diabetes, maternal smoking and syndromes with CHD. All patients that presented to the clinic between January 2020 and May of 2020 were included. An interviewer administered questionnaire was used to record the presence of maternal diabetes, maternal smoking, and the type of syndrome and type of CHD. Patients with CHD were included in the case group and patients who did not have CHD were in the control group. Age, gender, and nationality were also collected from the hospital records. Fisher exact test and logistic regression was used to analyze the results.Results: A total of 177 cases and 211 controls were recruited. All the risk factors increase the risk of CHD, with maternal diabetes (OR 6.3, 95% CI 2.7-14.6) having the strongest association, then syndromes (OR 5.1, 95% CI 2.3-11.3) and lastly maternal smoking (OR 4.0, 95% CI 1.0-16.3). The most common type of CHD is ventricular septal defect.Conclusion: Maternal diabetes, maternal smoking and syndromes are significant risk factors of CHD in children visiting Aljalila cardiology clinic. Action needs to be taken in order to decrease these risk factors and so, decrease the incidence of CHD in the future. Clearly, more research is needed in order to identify other risk factors for patients in the United Arab Emirates (UAE).
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Samah Alasrawi (2021) conducted a case-control in Congenital heart disease (CHD) (n=388). Maternal diabetes, maternal smoking, and syndromes vs. Absence of these risk factors was evaluated on Congenital heart disease (CHD) (OR 6.3, 95% CI 2.7-14.6). Maternal diabetes (OR 6.3; 95% CI 2.7-14.6), syndromes (OR 5.1; 95% CI 2.3-11.3), and maternal smoking (OR 4.0; 95% CI 1.0-16.3) were significantly associated with congenital heart disease.
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