Key result
Maternal diabetes linked to increased offspring CHD risk, peaking at ~37% incidence for type 1.
Why the study?
The risk and incidence of congenital heart defects in infants of diabetic mothers in Saudi Arabia were not well established at a tertiary hospital level.
Does maternal diabetes increase the incidence of congenital heart defects in offspring?
Population
1838 births from mothers aged 20-40 years in Saudi Arabia including diabetic and non-diabetic mothers
Comparison
Infants of diabetic mothers (type 1, type 2, gestational) versus non-diabetic mothers
Design
Retrospective cohort study
Authors
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May inform targeted CHD screening in Saudi IDMs; leaves open generalizability and need for adjusted prospective studies.
Cohort (n=1,838)
Yes
Does maternal diabetes increase the incidence of congenital heart defects in offspring?
p-value: p=<0.0001
Maternal diabetes, particularly Type 1 and Type 2, is associated with a higher incidence of congenital heart defects in offspring, most commonly patent ductus arteriosus and patent foramen ovale.
Alyousif et al. (2021) conducted a cohort in Congenital heart defects (n=1,838). Maternal diabetes vs. Non-diabetic mothers was evaluated on Incidence of congenital heart defects in offspring (p=<0.0001). Maternal diabetes was significantly associated with an increased incidence of congenital heart defects in offspring, particularly among mothers with type 1 (37.21%) and type 2 diabetes (25.76%) compared to non-diabetic mothers (10.25%).
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