Why the study?
Does diazepam reduce contractile force and calcium current in isolated guinea pig heart preparations?
Population
Isolated guinea pig Langendorff hearts, right ventricular free-wall preparations, and single ventricular…
Comparison
Diazepam administered via continuous perfusion. vs Baseline/control conditions without diazepam…
Design
Preclinical
Authors
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Hypothesis-generating for direct cardiac effects of diazepam; prospective human studies needed before clinical adoption.
Does diazepam reduce contractile force and calcium current in isolated guinea pig heart preparations?
Diazepam exerts a direct, concentration-dependent negative inotropic effect on the heart by inhibiting calcium channels in a state-independent manner, independent of central or peripheral benzodiazepine receptors.
Hara et al. (2001) studied this question.
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