January 1, 1999The Japanese Journal of PharmacologyOpen Access

Diazepam Increases Calcium Sensitivity of the Skinned Cardiac Muscle Fiber in Guinea Pig.

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Why the study?

Does diazepam increase calcium sensitivity in skinned cardiac muscle fibers of guinea pigs?

Population

Skinned trabecular fibers of guinea pig heart

Comparison

Diazepam (100 microM) vs Absence of diazepam

Design

Preclinical

Authors

YHYukio HaraNihon Pharmaceutical University ACAkihito ChugunTokiwa Park KFKeisuke FutamuraNagoya University

Discussion

Member takes

Implication

Does not support clinical use; hypothesis-generating for benzodiazepine effects on myocardial calcium sensitivity.

Structured PICO

Does diazepam increase calcium sensitivity in skinned cardiac muscle fibers of guinea pigs?

Population

Skinned trabecular fibers of guinea pig heart

Intervention

Diazepam (100 microM)

Comparator

Absence of diazepam

Outcome

Contractile response to calcium (pCa50 values)surrogate

Diazepam increases the calcium sensitivity of contractile proteins in guinea pig heart muscles.

Cite This Study

Hara et al. (1999) studied this question.

synapsesocial.com/papers/6a902184e73a4c404fc91f9c https://doi.org/10.1254/jjp.81.122

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Diazepam Increases Calcium Sensitivity of the Skinned Cardiac Muscle Fiber in Guinea Pig.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Diazepam Increases Calcium Sensitivity of the Skinned Cardiac Muscle Fiber in Guinea Pig.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider