Key result
A simple isocratic HPLC-UV-DAD method was developed and validated for ivabradine determination, demonstrating linearity from 5 to 100 µg/ml and usefulness for monitoring stress degradation products.
A simple, validated HPLC-UV-DAD method can accurately determine ivabradine concentrations and monitor its stress degradation products.
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Offers validated ivabradine assay for research; leaves open clinical or pharmacokinetic adoption pending further studies.
Nowakowska et al. (2017) studied this question. RP-HPLC method for determination of ivabradine was evaluated on Linearity, limits of detection (LOD), and limits of quantification (LOQ). A simple isocratic HPLC-UV-DAD method was developed and validated for ivabradine determination, demonstrating linearity from 5 to 100 µg/ml and usefulness for monitoring stress degradation products.
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