What question did this study set out to answer?

To determine the effects of exogenous corticotropin-releasing factor (CRF) on antropyloroduodenal motility, gastric emptying, and appetite in healthy humans.

January 1, 2002The American Journal of Gastroenterology

Effects of exogenous corticotropin-releasing factor on antropyloroduodenal motility and appetite in humans

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Authors

YSYu-Chung SuKaohsiung Medical University SDSelena DoranRoyal Adelaide Hospital GWGary WittertSouth Australia Pathology

Discussion

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Overview

Randomized double-blind trial reveals corticotropin-releasing factor stimulates upper gut motility in healthy adults, indicating stress hormones selectively modulate intestinal contractions.

Key Points

To determine the effects of exogenous corticotropin-releasing factor (CRF) on antropyloroduodenal motility, gastric emptying, and appetite in healthy humans.
Six healthy volunteers were evaluated on two separate days in a randomized, double-blind crossover design receiving intravenous CRF (1.0 µg/kg bolus plus 1.0 µg/kg/h constant infusion) or saline.
Upper gastrointestinal motor activity was recorded using sleeve and sidehole manometry following ingestion of a nutrient drink with paracetamol, and appetite was monitored via visual analog scales before a buffet meal.
CRF significantly increased serum cortisol (p < 0.001), isolated pyloric pressure waves (p < 0.05), total duodenal pressure waves (p < 0.05), and the percentage of antegrade duodenal pressure waves (p < 0.05).
CRF had no significant effect on antral pressure wave frequency, basal pyloric pressure, serum paracetamol concentrations, visual analog appetite ratings, or total caloric and macronutrient intake.

Cite This Study

Su et al. (2002) studied this question.

synapsesocial.com/papers/6a89b8f2d76717fba3eb2e46 https://doi.org/10.1111/j.1572-0241.2002.05422.x

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January 1, 2002The American Journal of Gastroenterology

Effects of exogenous corticotropin-releasing factor on antropyloroduodenal motility and appetite in humans

View Full Paper

Ask AI

Bookmark

Authors

YSYu-Chung SuKaohsiung Medical University SDSelena DoranRoyal Adelaide Hospital GWGary WittertSouth Australia Pathology

Discussion

Member takes

Overview

Randomized double-blind trial reveals corticotropin-releasing factor stimulates upper gut motility in healthy adults, indicating stress hormones selectively modulate intestinal contractions.

Key Points

To determine the effects of exogenous corticotropin-releasing factor (CRF) on antropyloroduodenal motility, gastric emptying, and appetite in healthy humans.
Six healthy volunteers were evaluated on two separate days in a randomized, double-blind crossover design receiving intravenous CRF (1.0 µg/kg bolus plus 1.0 µg/kg/h constant infusion) or saline.
Upper gastrointestinal motor activity was recorded using sleeve and sidehole manometry following ingestion of a nutrient drink with paracetamol, and appetite was monitored via visual analog scales before a buffet meal.
CRF significantly increased serum cortisol (p < 0.001), isolated pyloric pressure waves (p < 0.05), total duodenal pressure waves (p < 0.05), and the percentage of antegrade duodenal pressure waves (p < 0.05).
CRF had no significant effect on antral pressure wave frequency, basal pyloric pressure, serum paracetamol concentrations, visual analog appetite ratings, or total caloric and macronutrient intake.

Cite This Study

Su et al. (2002) studied this question.

synapsesocial.com/papers/6a89b8f2d76717fba3eb2e46 https://doi.org/10.1111/j.1572-0241.2002.05422.x

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