Why the study?
Recruitment and activation of brown adipocytes is a potential anti-obesity strategy, and thyroid hormones contribute to thermogenesis and induce white adipose depot browning.
This review summarizes the mechanisms by which thyroid hormones mediate brown adipose tissue activity and white adipose tissue browning, highlighting their relevance for thermoregulation and potential as a therapeutic approach for obesity.
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Should not yet change obesity management; leaves open cardiometabolic applications of thyroid-mediated adipose browning.
The recruitment and activation of energy-consuming brown adipocytes is currently considered as potential therapeutic approach to combat obesity. Thyroid hormones (TH) significantly contribute to full thermogenic capacity of brown adipocytes. A number of recent studies suggest that TH also induce the recruitment of brown adipocytes in white adipose depots, a process known as browning. In this review, we will summarize underlying mechanisms by which TH mediate brown adipose tissue activity and white adipose tissue browning. Furthermore, we will discuss the relevance of TH-induced white adipose tissue browning for thermoregulation.
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Volke et al. (2020) studied this question.
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