Key result
Tshr knockout reduces adiposity and promotes beige adipocyte development via AMPK/PRDM16/PGC1α in mice.
Why the study?
The connection between thyroid-stimulating hormone (TSH) and the browning of white adipose tissue, which affects energy expenditure and adiposity, has never been explored.
TSH regulates energy balance and adiposity by inhibiting the browning of white fat, suggesting a mechanism linking subclinical hypothyroidism to obesity.
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May link subclinical hypothyroidism to obesity via fat browning; leaves open human translation and therapeutic targeting.
Zhang et al. (2020) studied Adiposity. Thyroid-stimulating hormone (TSH) / Tshr-knockout was evaluated on Browning of white adipose tissue and energy metabolism. Increased TSH levels decrease energy expenditure and promote adiposity, while Tshr knockout decreases adiposity and promotes beige adipocyte development via AMPK/PRDM16/PGC1α.
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