Why the study?
Does digitalis glycoside administration alter the ventricular fibrillation threshold in innervated and denervated canine hearts?
Population
Open-chest anesthetized dogs (innervated and denervated hearts)
Comparison
Intravenous bolus infusion of… vs Control values
Design
Preclinical
Authors
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Digitalis effects on canine VFT depend on intact innervation; hypothesis-generating and should not alter clinical practice.
Does digitalis glycoside administration alter the ventricular fibrillation threshold in innervated and denervated canine hearts?
Digitalis increases the ventricular fibrillation threshold in healthy, innervated hearts via sympathetic activity, but decreases it in the absence of neural influences.
George et al. (1974) studied this question.
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