Key result
Digitalis affects AV node refractoriness via anti-adrenergic mechanisms abolished by total cardiac denervation.
Authors
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Digitalis AV nodal effects require intact autonomic innervation in dogs; extends mechanistic insight but leaves human relevance open.
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Schaal et al. (1968) studied this question. Digitalis exerts effects on the AV node functional refractory period via an anti-adrenergic influence, with these effects attenuated by vagotomy and abolished by total cardiac denervation.
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