January 1, 1997Journal of Cardiovascular Pharmacology

In Swine Myocardium, the Infarct Size Reduction Induced by U-89232 is Glibenclamide Sensitive: Evidence That U-89232 is a Cardioselective Opener of ATP-Sensitive Potassium Channels

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Why the study?

Does U-89232 reduce infarct size in a swine model of myocardial ischemia-reperfusion injury?

Structured PICO

Does U-89232 reduce infarct size in a swine model of myocardial ischemia-reperfusion injury?

Population

Open-chest pigs subjected to a 60-min occlusion of the left anterior descending coronary artery (LADCA) and 2 h of reperfusion (n=24, 4 groups of 6).

Intervention

U-89232 (3 mg/kg i.v. over 15 min) administered before LADCA occlusion.

Comparator

Saline (controls), glibenclamide (1 mg/kg i.v. over 15 min), or glibenclamide followed by U-89232.

Outcome

Infarct size (as percentage of risk region) determined by p-nitrobluetetrazolium incubation at the end of 2 hours of reperfusion.surrogate

U-89232 acts as a cardioselective KATP channel opener that provides profound cardioprotection against ischemia-reperfusion injury in a swine model without altering hemodynamics.

Discussion

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Implication

Supports cardioselective KATP openers for cardioprotection; leaves open translation to human ischemia-reperfusion injury.

Cite This Study

Rohmann et al. (1997) studied this question.

synapsesocial.com/papers/6a89c19ca14d41d02f432c63 https://doi.org/10.1097/00005344-199701000-00011

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In Swine Myocardium, the Infarct Size Reduction Induced by U-89232 is Glibenclamide Sensitive: Evidence That U-89232 is a Cardioselective Opener of ATP-Sensitive Potassium Channels

Structured PICO

Discussion

Implication

Cite This Study

In Swine Myocardium, the Infarct Size Reduction Induced by U-89232 is Glibenclamide Sensitive: Evidence That U-89232 is a Cardioselective Opener of ATP-Sensitive Potassium Channels

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider