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October 1, 2001Acta Anaesthesiologica Scandinavica

Intraoperative epidural blockade prevents the increase in protein breakdown after abdominal surgery

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Why the study?

Does intraoperative epidural blockade with bupivacaine prevent the increase in protein breakdown in patients undergoing cystoprostatectomy?

Population

14 patients undergoing cystoprostatectomy

Comparison

Combination of general anaesthesia and epidural… vs General anaesthesia with isoflurane

Design

RCT, randomly assigned

Follow-up

3 days after the operation

Authors

RLRalph LattermannRoyal Victoria HospitalTSThomas SchrickerMcGill University Health CentreUWUlrich WachterUniversität Ulm

Discussion

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Implication

Supports epidural use to blunt postoperative catabolism in major abdominal surgery; confirms metabolic benefits of regional anesthesia in RCT.

Structured PICO

Does intraoperative epidural blockade with bupivacaine prevent the increase in protein breakdown in patients undergoing cystoprostatectomy?

P
Population
14 patients undergoing cystoprostatectomy
I
Intervention
Combination of general anaesthesia and epidural blockade with bupivacaine from segment T4 to S5 restricted to the intraoperative period
C
Comparator
General anaesthesia with isoflurane
O
Outcome
Protein breakdown (calculated from urea production rate)surrogate

Intraoperative epidural blockade with bupivacaine prevents the increase in protein breakdown after major abdominal surgery.

Cite This Study

Lattermann et al. (2001) studied this question.

synapsesocial.com/papers/6a89c3366fc170cbc2fbbeachttps://doi.org/10.1034/j.1399-6576.2001.450915.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epidural analgesia improves postoperative nitrogen balance.1978 · 167 citations
  2. 2Nitrogen-Sparing Effect of Epidural Administration of Local Anesthetics in Colon Surgery1989 · 62 citations
  3. 3The independent metabolic effects of halo thane and isoflurane anaesthesia1993 · 43 citations
  4. 4Intestinal Hemodynamics During Laparotomy1990 · 65 citations
  5. 5Haemodynamics and Oxygen Consumption in the Dog During High Epidural Block with Special Reference to the Splanchnic Region1983 · 45 citations