September 7, 2005European Journal of Cardio-Thoracic SurgeryOpen Access

31P MRS of heart grafts provides metabolic markers of early dysfunction

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Why the study?

Does ex vivo 31P MRS of heart grafts provide metabolic markers that predict early graft failure?

Population

26 heart grafts harvested in the vicinity of the transplantation centre over a 3-year period

Design

Cohort

Follow-up

early post-transplant (weaning from CPB)

Authors

TCThierry CausCentre Hospitalier Universitaire Amiens-Picardie FKFrank KoberCardiac Imaging AMAnnick Mouly-BandiniAssistance Publique Hôpitaux de Marseille

Discussion

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Implication

Ex vivo 31P MRS markers were associated with graft outcomes; hypothesis-generating and should not yet change practice.

Structured PICO

Does ex vivo 31P MRS of heart grafts provide metabolic markers that predict early graft failure?

Population

26 heart grafts harvested in the vicinity of the transplantation centre over a 3-year period

Intervention

Ex vivo (31)P magnetic resonance spectroscopy (MRS) performed approximately 60min after aortic cross-clamp to quantify ATP, Pi and PCr concentration ratios

Outcome

Early graft failure (EGF) defined as the need to abnormally extend circulatory support or to use more than two inotropes before weaning the patient from CPB after transplantationsurrogate

Ex vivo 31P MRS of heart grafts provides metabolic markers that significantly correlate with early graft failure after transplantation.

Cite This Study

Caus et al. (2005) studied this question.

synapsesocial.com/papers/6a89c8451fb56efa37d46ee4 https://doi.org/10.1016/j.ejcts.2005.07.009

Topics

Heart transplantation

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31P MRS of heart grafts provides metabolic markers of early dysfunction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

31P MRS of heart grafts provides metabolic markers of early dysfunction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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