July 1, 1999Journal of Biological ChemistryOpen Access

Cloning and Characterization of a Novel RING Finger Protein That Interacts with Class V Myosins

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Population

Yeast two-hybrid system and PC12 cells

Design

Preclinical

Authors

AEAlaa El-HusseiniUniversity of British Columbia SVSteven R. VincentThe University of Sydney

Discussion

Member takes

Implication

Should not alter clinical practice; leaves open BERP-myosin V role in neurite outgrowth pending in vivo confirmation.

Structured PICO

Population

Yeast two-hybrid system and PC12 cells

Intervention

Stable expression of a mutant form of BERP lacking the myosin-binding domain but containing the dimerization domain

Outcome

PC12 cell spreading and neurite outgrowth in response to nerve growth factorsurrogate

Identifies BERP as a novel interacting partner for class V myosins, providing evidence for its role in myosin V-mediated cargo transport and neurite outgrowth.

Cite This Study

El-Husseini et al. (1999) studied this question.

synapsesocial.com/papers/6a89c9b2abb0ef83c5c99269 https://doi.org/10.1074/jbc.274.28.19771

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Cloning and Characterization of a Novel RING Finger Protein That Interacts with Class V Myosins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cloning and Characterization of a Novel RING Finger Protein That Interacts with Class V Myosins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider