Why the study?
Does elevated asymmetrical dimethylarginine (ADMA) mediate renal microvascular endothelial dysfunction in a canine model of chronic renal failure?
Population
Male mongrel dogs with chronic renal failure (CRF) established by subtotal nephrectomy
Comparison
Intrarenal arterial infusion of acetylcholine… vs Normal dogs
Design
Preclinical
Follow-up
4 weeks
Authors
Loading...
May implicate ADMA in experimental CRF endothelial dysfunction; hypothesis-generating and leaves open human translation.
Does elevated asymmetrical dimethylarginine (ADMA) mediate renal microvascular endothelial dysfunction in a canine model of chronic renal failure?
Elevated ADMA and downregulation of DDAH-II contribute to renal microvascular endothelial dysfunction and impaired nitric oxide production in chronic renal failure.
Okubo et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: