Clinicians should be aware of coronary artery disease as a very late complication of chest radiation therapy, even in patients without conventional coronary risk factors.
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Alerts clinicians to very late radiation-induced coronary occlusion causing HF; leaves open optimal long-term surveillance in survivors.
We report the case of a 51-year-old female, in whom coronary artery disease such as occlusion of septal perforators was manifested, on the occasion of hospitalization with congestive heart failure. The patient had a history of radiation therapy for a mediastinal tumor 19 years previously. As she had no conventional coronary risk factors, the cause of the coronary artery disease is thought to have been related to the radiation therapy. As survival rates of cancer patients improve as a consequence of therapeutic advances, we should be aware of the possibility of coronary artery disease as a very late complication of radiation therapy, even in patients who have no coronary risk factors.
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Inami et al. (2017) studied this question.
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