Why the study?
Diagnosing platelet function disorders in children is challenging because gold-standard light transmission aggregometry requires large blood volumes, and tools using small blood volumes are lacking.
Can flow cytometric assessment of AKT signaling detect platelet activation using small blood volumes?
Population
Healthy volunteers
Comparison
Platelet activation with various agonists vs nonactivated platelets
Design
In vitro experimental study
Authors
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Offers potential small-volume pediatric platelet testing alternative; hypothesis-generating from animal data only.
Can flow cytometric assessment of AKT signaling detect platelet activation using small blood volumes?
Flow cytometric assessment of AKT signaling can detect platelet activation, offering a potential alternative to light transmission aggregometry for testing platelet function in children using small blood volumes.
Althaus et al. (2020) studied this question.
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