Population
In vitro cell models and in vivo models infected with coxsackievirus B3 (CVB3)
Comparison
Interferon-beta alone or in combination with… vs Untreated controls or IFN-β alone
Design
Preclinical
Authors
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Should not change clinical management of viral myocarditis; hypothesis-generating for metformin-IFN-β synergy in animal models only.
IFN-β regulates glucose metabolism to support antiviral responses against Coxsackievirus B3, an effect that can be enhanced by the insulin-sensitizing drug metformin.
Burke et al. (2014) studied this question.
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