Why the study?
Does the measurement of albumin/creatinine ratios in early morning urine specimens accurately detect microalbuminuria compared to timed overnight urine specimens in diabetic patients?
Does the measurement of albumin/creatinine ratios in early morning urine specimens accurately detect microalbuminuria compared to timed overnight urine specimens in diabetic patients?
An early morning urine albumin/creatinine ratio >= 2.0 mg/mmol is a highly sensitive and specific screening test for diabetic microalbuminuria, simplifying routine clinical care.
Supports early morning ACR >=2.0 mg/mmol for microalbuminuria screening in diabetes; leaves open prospective validation before practice change.
The measurement of albumin/creatinine ratios and simple albumin concentrations in early morning urine specimens were evaluated to establish which was the best screening test for those likely to have microalbuminuria by the reference standard analysis of timed overnight urine specimens. The measurement of an albumin/creatinine ratio with a cut off of > or = 2.0 mg/mmol was found to be suitable with a specificity of 93% and sensitivity of 97%.
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Hunt et al. (1995) studied this question.
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