A novel gear-piston pumping system can accurately replicate physiological blood flow waveforms for in vitro vascular experiments.
Supports high-fidelity in vitro arterial waveform replication; leaves open translation to clinical vascular testing.
A pulsatile flow pumping system is developed to replicate flow waveforms with reasonable accuracy for experiments simulating physiological blood flows at numerous points in the body. The system divides the task of flow waveform generation between two pumps: a gear pump generates the mean component and a piston pump generates the oscillatory component. The system is driven by two programmable servo controllers. The frequency response of the system is used to characterize its operation. The system has been successfully tested in vascular flow experiments where sinusoidal, carotid, and coronary flow waveforms are replicated.
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Tsai et al. (2010) studied this question.
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