Key result
A fully programmable pulsatile flow pump using an iterative control algorithm accurately replicated physiological flow waveforms with RMSEs of 0.64 L/min for flow rate and 0.52 mL for stroke volume.
Why the study?
In-vitro cardiovascular experiments characterize medical devices without ethical issues or in-vivo costs, but require fully programmable pulsatile pumps that accurately reproduce physiological waveforms without costly transient flowmeters.
A newly designed fully programmable pulsatile flow pump using an iterative control algorithm can accurately reproduce physiological flow waveforms for in-vitro cardiovascular experiments.
In-vitro models may reduce costs and ethical burdens for device testing; leaves open clinical translation pending in-vivo validation.
In-vitro cardiovascular experiments provide an effective means for characterizing structural or hemodynamic features of medical devices before they are tested on animals or used in clinical practice. In-vitro experiments simulate complicated cardiovascular systems with blood pumps, vessels and valves, but without human or animal subjects. Therefore, such experiments are free from ethical issues and present large cost savings in comparison to in-vivo experiments. In this study, we aimed to design a fully programmable pulsatile flow pump that can consistently and accurately reproduce a wide range of physiological flow waveforms without costly transient flowmeter in the system. An iterative control algorithm (ICA) was used to minimize the differences between the desired and produced flow waveforms. Our results confirm that the developed pulsatile pump can replicate flow waveforms accurately, with root mean square errors (RMSEs) of 0.64 L/min and 0.52 mL for the flow rate and stroke volume, respectively.
No takes yet. Share an insight, caveat, or question.
Kim et al. (2020) studied this question. Pulsatile flow pump based on an iterative controlled piston pump actuator was evaluated on Accuracy of replicating flow waveforms (root mean square errors for flow rate and stroke volume). A fully programmable pulsatile flow pump using an iterative control algorithm accurately replicated physiological flow waveforms with RMSEs of 0.64 L/min for flow rate and 0.52 mL for stroke volume.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: