Why the study?
Does parainfluenza 3 infection enhance contractile responses to substance P and capsaicin in guinea pig airway smooth muscle?
Population
Guinea pigs (left bronchial ring segments)
Comparison
Parainfluenza 3 infection via nasal insufflation… vs Virus growth medium
Design
Preclinical
Follow-up
4 days
Authors
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May implicate lipoxygenase pathway in virus-enhanced airway contractility; hypothesis-generating for human asthma exacerbations, should not change practice.
Does parainfluenza 3 infection enhance contractile responses to substance P and capsaicin in guinea pig airway smooth muscle?
Parainfluenza 3 infection enhances airway smooth muscle contractile responses to substance P and capsaicin via a mechanism involving the lipoxygenase pathway of arachidonic acid metabolism.
Saban et al. (1987) studied this question.
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