The envelope protein of the Mason-Pfizer monkey virus possesses immunosuppressive properties in vivo, extending previous findings from murine retroviruses to primate retroviruses.
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Caution against human translation; extends retroviral envelope immunosuppression from murine to primate models in vivo.
We have demonstrated previously that the envelope protein of a murine retrovirus, Moloney murine leukaemia virus, has immunosuppressive properties in vivo. This property was manifested by the ability of the protein, when expressed by tumour cells normally rejected by engrafted mice, to allow the env-expressing cells to escape immune rejection and to proliferate. Here, it is shown that this property is not restricted to the envelope of a murine retrovirus, but is also shared by the envelope encoded by a primate retrovirus, Mason-Pfizer monkey virus.
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Blaise‐Boisseau et al. (2001) studied this question.
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