November 30, 2009Journal of Medical VirologyOpen Access

Pro‐inflammatory response resulting from sindbis virus infection of human macrophages: Implications for the pathogenesis of viral arthritis

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Why the study?

Does Sindbis virus infection induce a pro-inflammatory response in human macrophages, and is this response mediated by macrophage migration inhibitor factor (MIF)?

Population

Human macrophages and knockout mice for the MIF gene

Comparison

Sindbis virus (SinV) infection vs MIF blockade strategies

Design

Preclinical

Authors

IAIranaia Assunção‐MirandaUniversidade Federal do Rio de Janeiro MBMarcelo T. BozzaUniversidade Federal do Rio de Janeiro APAndrea T. Da PoianUniversidade Federal do Rio de Janeiro

Discussion

Member takes

Implication

MIF may mediate viral macrophage activation in models; leaves open translation to human inflammatory disease.

Structured PICO

Does Sindbis virus infection induce a pro-inflammatory response in human macrophages, and is this response mediated by macrophage migration inhibitor factor (MIF)?

Population

Human macrophages and knockout mice for the MIF gene

Intervention

Sindbis virus (SinV) infection

Comparator

MIF blockade strategies (anti-MIF antibody, MIF inhibitor ISO-1, and MIF knockout mice)

Outcome

Macrophage activation, release of macrophage migration inhibitor factor (MIF), and expression/secretion of TNF-alpha, IL-1beta, IL-6, and matrix metalloproteinases (MMPs) 1 and 3surrogate

Sindbis virus infection induces a pro-inflammatory response in human macrophages that is regulated by MIF, revealing similarities to the pathogenesis of rheumatoid arthritis.

Cite This Study

Assunção‐Miranda et al. (2009) studied this question.

synapsesocial.com/papers/6a8a402f1fb56efa37d48c0f https://doi.org/10.1002/jmv.21649

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Pro‐inflammatory response resulting from sindbis virus infection of human macrophages: Implications for the pathogenesis of viral arthritis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pro‐inflammatory response resulting from sindbis virus infection of human macrophages: Implications for the pathogenesis of viral arthritis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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