Key result
S.A.AR86 alphavirus replicates within periosteum, tendons, and endosteum near articular joints in adult mice.
Population
Adult mouse model
Design
Preclinical
Follow-up
1 to 6 days postinfection
Authors
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Hypothesis-generating for alphavirus arthralgia mechanisms in mice; leaves open translation to human disease.
In an adult mouse model, arthralgia-associated alphaviruses replicate within bone-associated connective tissue adjacent to articular joints, providing insight into the mechanisms of alphavirus-induced arthralgia.
Heise et al. (2000) studied Alphavirus-induced arthralgia and arthritis. S.A.AR86 (Sindbis-group alphavirus) inoculation was evaluated on Localization of viral replication. In an adult mouse model, S.A.AR86 alphavirus replicated within the periosteum, tendons, and endosteum adjacent to articular joints 1 to 6 days postinfection.
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