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December 1, 1981BloodOpen Access

Platelet von Willebrand's antigen II: active release by aggregating agents and a marker of platelet release reaction in vivo

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Population

Washed platelets and patients with clinical syndromes associated with intravascular platelet destruction

Design

Preclinical

Authors

JSJP ScottMayo Clinic in ArizonaRMRR MontgomeryRensselaer Polytechnic Institute

Discussion

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Implication

Animal data support vW AgII release during aggregation; leaves open its role as a human platelet destruction marker.

Structured PICO

P
Population
Washed platelets and patients with clinical syndromes associated with intravascular platelet destruction
I
Intervention
Aggregation by thrombin, collagen, and adenosine diphosphate (ADP)
O
Outcome
Release of platelet von Willebrand's antigen II (vW AgII)surrogate

vW AgII is actively released from platelets during aggregation and serves as a marker of intravascular platelet destruction.

Cite This Study

Scott et al. (1981) studied this question.

synapsesocial.com/papers/6a8a41960f137e402b337b50https://doi.org/10.1182/blood.v58.6.1075.1075
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Comparison of Methods for the Study of Platelet Hyperfunction in Thrornboembolic Disorders1980 · 24 citations
  2. 2Platelet and Fibrinogen Consumption in Man1972 · 490 citations
  3. 3Platelet-associated IgG in immune thrombocytopenic purpura1977 · 139 citations
  4. 4Metabolism and Function of Human Platelets Washed by Albumin Density Gradient Separation1977 · 163 citations